AstraZeneca PLC is a large Anglo-Swedish pharmaceutical company formed on 6 April 1999 by the merger of Swedish Astra AB and British Zeneca Group plc. Lots of people say that AstraZeneca PLC is leading in the various studies conducted in the fight against prostate cancer. In the foregoing paragraphs I will tell you more about the usage of the drug they produced that is being used for clinical trials. It works by specific blockade of the ETA receptor, inhibiting tumor cell proliferation, tumor cell survival, tumor angiogenesis and the pathophysiology of bone metastases in prostate malignant cancer patients.
According to John Patterson, AstraZeneca's Executive Director for Development: "The mainstay treatment for prostate cancer - a cancer driven by naturally occurring male hormones - is hormonal therapy... Whilst such therapy provides great benefit for many men, the majority of patients eventually become resistant to hormonal treatments. For these men there are currently few proven options apart from chemotherapy, and the prognosis is often poor. ZD4054 offers a novel potential treatment."
AstraZeneca has indeed done well in the past, with hormotherapeutic drugs ZOLADEX (goserelin) and CASODEX (bicalutamide), first launched in 1987 and 1995 respectively. Phase III studies are randomized controlled multicenter trials on large patient groups (300-3,000 or more depending upon the disease/medical condition studied) and are aimed at being the definitive assessment of how effective the drug is. They are the most expensive, time-consuming and difficult trials to design and run, especially in therapies for chronic medical conditions like prostate cancer definitely is.
I suppose we need to give them a chance to prove themselves; for all we know ZD4054 may be it. Prostate carcinoma affects close two hundred thousand new men each year in the United States alone, and kills about twenty seven thousand. At the very least, we can afford better treatments for the carcinoma.
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Find information on Clinical Trials at CheckTheProstate.com